Before I get angry emails and tweets, let me start out by saying that I like Kamara. I really do. He is a fun and explosive player with tremendous upside and had a monster rookie year. My problems with Kamara aren't that he is a bad player, my issues with Kamara stem from the fact that he is being taken 5th overall. He's going before Antonio Brown in most draft.
Let's start with the fact that Kamara is in his second year, and is still (at least to me) a little unproven. Yes, he had a fantastic first year (1,500 total yards and 12 TDs), but can that be maintained without Mark Ingram around to carry some of the load? Kamara is, after all, going to be the only running back on this team for four games. Will he be able to do it? Will this affect his longterm abilities for the season? In my opinion, you can't expect this because nobody knows if he can handle it.
I think what made him so good last year was this thunder, lightning approach to running the ball with Ingram, and I find it realistic to believe that without the other half being there he will suffer tremendously.
What Should I Do Instead?: Take Antonio Brown. Antonio Brown is Alvin Kamara's ceiling, and he is going after Brown. Regarding the New Orleans backfield (and if you want to make a better fantasy move) take Ingram at 55. He almost always finishes in the top 15 for RBs, even if he is out for a few games with an injury. I know you'll have to patch it together for the first four weeks, but having Ingram, a solid low-end RB1, you can get in round 5 is a steal. You will have this guy for the fantasy playoffs, and he would be your flex or fill in for bye weeks.